Hepatic encephalopathy HE is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism, systemic inflammatory response and alterations of the blood brain barrier. HE produces a wide spectrum of nonspecific neurological and psychiatric manifestations. Minimal HE is diagnosed by abnormal psychometric tests.
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Alternativamente, as ROS podem ativar a tirosina para formar tirosil, um radical que, por sua vez oxida No para produzir nitrotirosina. Sener et al. GSA e MG foram acentuadamente mais potentes como convulsivantes do que a guanidina e creatinina.
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