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The LRRK2 GR variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions. LRRK2 protein contains several functional domains, including protein-protein interaction domains at its N- and C-termini. We found that N- and C-terminal domains have opposite impact on synaptic vesicle dynamics. Complementary biochemical and imaging approaches revealed that the GR variant alters strength and quality of LRRK2 interactions and increases fusion of synaptic vesicles.
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Louis Kuhne 14 March — 4 April was a German naturopath primarily known for his cold water hydrotherapy methods that were meant to improve. Hippocrates is famous for studying the healing powers of water, and subsequently creating thalassotherapy. Relevant discussion may be found on the talk page. This article has multiple issues.