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Branden, C. Introduction to protein structure, second ed. Garland publishing. The unique properties of protein molecules have motivated researchers exploit them in the design and fabrication of bio-mimetic nano devices to perform a special task. Function of protein molecules is in turn dependent on their 3D structure and their ability to modify their shape for a specific task.
To study and manipulate protein molecules we need to have knowledge of mechanical properties of these molecules. In this paper a multiscale model to predict stiffness of helical protein molecules has been developed. Hydrogen bonds as major contributing factor to proteins flexibility, are modeled as elastic springs based on their empirical potential energy.
Such mechanical representation of hydrogen bonds enables us to obtain the stiffness ellipsoid of hydrogen bonds which leads to an understanding of the directional stiffness of protein molecules. The model has also been applied to three different protein molecules whose stiffness were reported in the literature. Follow Us.
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NCBI Bookshelf. Molecular Biology of the Cell. New York: Garland Science; By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.
Introduction to protein structure / Carl Branden, John Tooze.
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