This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease.
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Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities. The diagnosis is based on the clinical appearance in association with the typical histologic features of orthohyperkeratosis and a subepidermal band-like infiltrate.
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Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities.
Similar articles Hyperkeratosis lenticularis perstans Flegel's disease --lack of response to treatment with tacalcitol and calcipotriol. Blaheta HJ, et al. PMID: An unusual generalized form of hyperkeratosis lenticularis perstans Flegel's disease.
Wien Klin Wochenschr. Long-standing spiny papules on the lower extremities. Flegel disease, or hyperkeratosis lenticularis perstans HLP. Humphrey S, et al. Arch Dermatol. PMID: No abstract available. Med Cutan Ibero Lat Am. PMID: Review. Hyperkeratosis lenticularis perstans Flegel's disease : our experience and review of the literature. Bortoluzzi P, et al. Int J Dermatol. Online ahead of print. Show more similar articles See all similar articles. Publication types Case Reports Actions. Biopsy Actions.
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Hyperkeratosis lenticularis perstans
DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Flegel disease is a rare dermatosis characterized by asymptomatic hyperkeratotic papules predominantly on the dorsa of the feet and lower legs. Clinical input is often very helpful in making a diagnosis histopathologically. The disorder is thought to be caused by alterations in the membrane-coating granules lamellar granules, Odland bodies of the keratinocytes. In Flegel disease, sections show discrete zones of compact lamellar hyperkeratosis with focal parakeratosis figure 1. The epidermis under the hyperkeratosis is atrophic compared with the surrounding skin, and the granular layer is attenuated absent figure 2.
DermNet provides Google Translate, a free machine translation service. Note that this may not provide an exact translation in all languages. Flegel disease is also known as hyperkeratosis lenticularis perstans. It was first described by Flegel in
Flegel disease pathology
Alternative titles; symbols. The disorder was first described by Flegel summary by Bean, Bean reported 3 members of the same family with HLP. Another member of the family was reported by Bean All 4 affected members in 3 generations had onset between the fourth and seventh decade of scattered reddish-brown discrete papules primarily affecting the extremities but also involving the thighs and trunk.
Hyperkeratosis Lenticularis Perstans (Flegel’s disease)
Editorial Board. Current Issue. Online Early. Coming Soon. Hyperkeratosis lenticularis perstans: Case report of a rare entity. How to cite this article: Patel KB.